The fourth placed Stars are coming off a massive win over the Adelaide Strikers, while the last placed Renegades are playing for pride after their last loss to the Heat ended their finals hopes.
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The Stars will look to skipper Glenn Maxwell to turn around an indifferent run of form with the bat, while Adam Zampa looms as the danger man with the ball.
For the Renegades Australian skipper Aaron Finch will be the key at the top of the order, while pace bowler Kane Richardson will be crucial to their hopes of climbing off the bottom of the ladder.
It sets the scene for an intriguing clash at the MCG with both sides having plenty to play for.
It started horribly for Aaron Finch when he was dismissed second ball of the match for a duck. In the third over, the Renegades are 1-21 with Shaun Marsh and Sam Harper at the crease.
Melbourne Stars: Marcus Stoinis, Andre Fletcher, Nick Larkin, Glenn Maxwell (C), Nic Maddinson, Hilton Cartwright, Seb Gotch (WK), Adam Zampa, Liam Hatcher, Billy Stanlake, Zahir Khan X-factors: Sam Rainbird, Ed Newman
Melbourne Renegades: Aaron Finch (C), Shaun Marsh, Sam Harper (WK), Jake Fraser-McGurk, Mackenzie Harvey, Beau Webster, Will Sutherland, Imad Wasim, Kane Richardson, Peter Hatzoglou, Noor Ahmad X-factors: Josh Lalor, Brayden Stepien
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