Ebene Magazine – A psychedelic drug holds great promise for those with PTSD

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(News)
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Ecstasy appears to be on track to become an FDA-cleared prescription treatment if the results of the first Phase 3 study of psychedelic assisted therapy are indications. According to the New York Times, 67% of PTSD patients who were given a dose of the drug while on therapy did not qualify for a PTSD diagnosis two months after treatment. This was compared to 32% of PTSD patients who were given a placebo. There was evidence that ecstasy, also known as MDMA, helped therapy patients in the late 1970s before it became a recreational drug and was criminalized in 1985. It improves the release of serotonin and dopamine, both of which regulate mood. A 2019 study in mice found that MDMA can also restore the brain to a « malleable state, » according to the Times. But « it’s the therapy that the drug improves, » that does the work here, says senior writer Rick Doblin of the Multidisciplinary Association for Psychedelic Studies.

Ninety participants in the United States, Canada, and Israel, most of whom were white, attended two sessions with trained therapists before being given MDMA or an inactive placebo over eight eight-hour sessions. One participant said his debilitating nightmares stopped after his sessions, which resulted in him reliving important memories of a 2007 deployment to Iraq and then dealing with what he called the PTSD bully. The « medicine … stimulated the ability of my own consciousness to heal itself, » the man told The Times. « I am literally a different person. » Another participant revisited a traumatic experience from age 4. « It allowed me to accept myself and see who I am, » he says. « It really made me understand what the feeling of joy is. » The only side effects, according to the Times, were mild nausea and loss of appetite. If the results of a second, ongoing Phase 3 study are just as promising, the FDA could approve MDMA-assisted therapy by 2023. (Read more MDMA stories.)

Ref: https://www.newser.com

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